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Importantly, it further upregulated the expression of FNDC5 mRNA and protein in the pancreas (Figures 2BD), agreeing with the results from the human and rat cell lines (Figure 1)

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The broader receptor profile of these newer-generation GLP-1 receptor agonists is thought to offer clinical advantages, potentially providing better tolerability or enhanced effectiveness due to simultaneous modulation of reward-related neural circuits and metabolic pathways (Ray 2023